Anatomy & Physiology
Occupational & Environmental Medicine
Bazex syndrome (acrokeratosis paraneoplastica)
Bazex syndrome denotes an acral psoriasiform dermatosis in association with internal malignancy. Elderly patients, usually males, present with a symmetric erythematous or violaceous, scaly eruption affecting the ears, nose, fingers, and toes. The knees and elbows may sometimes be involved. Vesicles and bullae are less common manifestations. In patients with black or darkbrown skin, the lesions can present with hyperpigmentation. Palmoplantar lesions are keratodermatous and nail involvement ranges from paronychia, horizontal or vertical ridging, yellow discoloration and thickening to onycholysis and subungual keratotic debris.
Patients with Bazex syndrome invariably have an associated systemic malignancy, most often affecting the oropharynx, larynx, esophagus, and lung, in descending order of frequency. Cervical lymph node metastases are commonly present. persistence of the cutaneous lesions is rare and they commonly regress following successful treatment of the underlying malignancy.
Source: P. McKee, J. Calonje - McKee's Pathology of the Skin (Elsevier)
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